2011年1月27日木曜日

Representation of Others' Action by Neurons in Monkey Medial Frontal Cortex

Kyoko Yoshida, Nobuhito Saito, Atsushi Iriki, Masaki Isoda
Current Biology 21, 1–5, February 8, 2011

自己と他者を区別するMFCニューロン
(MFC: medial frontal cortex)

他人が意思決定をするのを見ているトライアル、自分が意思決定するトライアルが交互に現れる。
(他人の意思決定の結果の情報を、次の自分の意思決定で使えるのがポイント)

主に2種類のニューロンが見られた。
Self type: 自己の意思決定時に反応
Other type: 他者の意思決定時に反応
あと、少数だけど Mirror type(自己と他者両方に反応)も見られた。

おもしろいことに、
dorsal(preSMA含む)にはSelf typeが多くて、ventral(rostral cingurate含む)にはOther typeが多かった。

→ MFCが他者の行動と自己の行動を区別するのに重要だろう。

Nature Neuroscienceあたりに載ってもおかしくない研究だと思ったけど…

Successful social interaction depends on not only the ability to identify with others but also the ability to distinguish between aspects of self and others [1-4]. Although there is considerable knowledge of a shared neural substrate between self-action and others' action [5], it remains unknown where and how in the brain the action of others is uniquely represented. Exploring such agent-specific neural codes is important because one's action and intention can differ between individuals [1]. Moreover, the assignment of social agency breaks down in a range of mental disorders [6-8]. Here, using two monkeys monitoring each other's action for adaptive behavioral planning, we show that the medial frontal cortex (MFC) contains a group of neurons that selectively encode others' action. These neurons, observed in both dominant and submissive monkeys, were significantly more prevalent in the dorsomedial convexity region of the MFC including the pre-supplementary motor area than in the cingulate sulcus region of the MFC including the rostral cingulate motor area. Further tests revealed that the difference in neuronal activity was not due to gaze direction or muscular activity. We suggest that the MFC is involved in self-other differentiation in the domain of motor action and provides a fundamental neural signal for social learning.

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