2011年11月23日水曜日

Expectancy-related changes in firing of dopamine neurons depend on orbitofrontal cortex

Yuji K Takahashi, Matthew R Roesch, Robert C Wilson, Kathy Toreson, Patricio O'Donnell, Yael Niv and Geoffrey Schoenbaum
Nature Neuroscience 14, 1590–1597 (2011)

The orbitofrontal cortex (OFC) has been hypothesized to carry information regarding the value of expected rewards. Such information could be used for generating instructive error signals conveyed by dopamine neurons. Here the authors report that this is indeed the case. However, contrary to the simplest hypothesis, OFC lesions did not result in the loss of all value information. Instead, lesions caused the loss of value information derived from model-based representations.

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