2012年9月27日木曜日

Disruption of Reconsolidation Erases a Fear Memory Trace in the Human Amygdala


Thomas Agren, Jonas Engman, Andreas Frick, Johannes Björkstrand, Elna-Marie Larsson, Tomas Furmark, Mats Fredrikson
Science 21 September 2012: Vol. 337 no. 6101 pp. 1550-1552

Memories become labile when recalled. In humans and rodents alike, reactivated fear memories can be attenuated by disrupting reconsolidation with extinction training. Using functional brain imaging, we found that, after a conditioned fear memory was formed, reactivation and reconsolidation left a memory trace in the basolateral amygdala that predicted subsequent fear expression and was tightly coupled to activity in the fear circuit of the brain. In contrast, reactivation followed by disrupted reconsolidation suppressed fear, abolished the memory trace, and attenuated fear-circuit connectivity. Thus, as previously demonstrated in rodents, fear memory suppression resulting from behavioral disruption of reconsolidation is amygdala-dependent also in humans, which supports an evolutionarily conserved memory-update mechanism.

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