2012年12月6日木曜日

Critical Roles for Anterior Insula and Dorsal Striatum in Punishment-Based Avoidance Learning


Stefano Palminteri, Damian Justo, Céline Jauffret, Beth Pavlicek, Aurélie Dauta, Christine Delmaire, Virginie Czernecki, Carine Karachi, Laurent Capelle, Alexandra Durr, Mathias Pessiglione
Neuron, Volume 76, Issue 5, 6 December 2012, Pages 998–1009

前島皮質または背側線条体に障害のある患者は損失回避学習が(報酬獲得学習に比べて)うまくできない。強化学習モデルを行動にフィットした結果、「健常者に比べて、前者の患者は損失に鈍感であり、後者の患者は行動選択の精度が低い」ことが分かった。

The division of human learning systems into reward and punishment opponent modules is still a debated issue. While the implication of ventral prefrontostriatal circuits in reward-based learning is well established, the neural underpinnings of punishment-based learning remain unclear. To elucidate the causal implication of brain regions that were related to punishment learning in a previous functional neuroimaging study, we tested the effects of brain damage on behavioral performance, using the same task contrasting monetary gains and losses. Cortical and subcortical candidate regions, the anterior insula and dorsal striatum, were assessed in patients presenting brain tumor and Huntington disease, respectively. Both groups exhibited selective impairment of punishment-based learning. Computational modeling suggested complementary roles for these structures: the anterior insula might be involved in learning the negative value of loss-predicting cues, whereas the dorsal striatum might be involved in choosing between those cues so as to avoid the worst.

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