2013年1月30日水曜日

Choice Coding in Frontal Cortex during Stimulus-Guided or Action-Guided Decision-Making


Chung-Hay Luk and Jonathan D. Wallis
The Journal of Neuroscience, 30 January 2013, 33(5): 1864-1871; doi: 10.1523/​JNEUROSCI.4920-12.2013

サル電気生理。ACCとOFCは共に報酬に基づく意思決定に関係すると考えられているが、ACCは「行動ー報酬」連合を手掛かりにした意思決定に、OFCは「刺激ー報酬」連合を手掛かりにした意思決定に主に関与している。 http://www.jneurosci.org/content/33/5/1864

To optimally obtain desirable outcomes, organisms must track outcomes predicted by stimuli in the environment (stimulus–outcome or SO associations) and outcomes predicted by their own actions (action–outcome or AO associations). Anterior cingulate cortex (ACC) and orbitofrontal cortex (OFC) are implicated in tracking outcomes, but anatomical and functional studies suggest a dissociation, with ACC and OFC responsible for encoding AO and SO associations, respectively. To examine whether this dissociation held at the single neuron level, we trained two subjects to perform choice tasks that required using AO or SO associations. OFC and ACC neurons encoded the action that the subject used to indicate its choice, but this encoding was stronger in OFC during the SO task and stronger in ACC during the AO task. These results are consistent with a division of labor between the two areas in terms of using rewards associated with either stimuli or actions to guide decision-making.

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