2013年1月4日金曜日

Neuronal reference frames for social decisions in primate frontal cortex


Steve W C Chang, Jean-François Gariépy, Michael L Platt
Nature Neuroscience (2012) doi:10.1038/nn.3287
Received 01 October 2012 Accepted 20 November 2012 Published online 23 December 2012

サル電気生理。条件つけ課題:刺激A→自分に報酬、B→他者に報酬、C→報酬なし。
OFCニューロンは自分の報酬、ACCgは自分が報酬を得られない時、ACCsは自分/他者の報酬両方に反応。
ACCsが他者効用の計算など社会的意思決定に特に重要。

ちなみに、ACCsは前帯状「溝(sulcus)」で、ACCgは前帯状「回(gyrus)」でACCsと脳梁の間の部分。またOFCは「lateral OFC」で、所謂vmPFCとは違う場所。この辺は http://www.ncbi.nlm.nih.gov/pubmed/21689594 に詳しい。

Social decisions are crucial for the success of individuals and the groups that they comprise. Group members respond vicariously to benefits obtained by others, and impairments in this capacity contribute to neuropsychiatric disorders such as autism and sociopathy. We examined the manner in which neurons in three frontal cortical areas encoded the outcomes of social decisions as monkeys performed a reward-allocation task. Neurons in the orbitofrontal cortex (OFC) predominantly encoded rewards that were delivered to oneself. Neurons in the anterior cingulate gyrus (ACCg) encoded reward allocations to the other monkey, to oneself or to both. Neurons in the anterior cingulate sulcus (ACCs) signaled reward allocations to the other monkey or to no one. In this network of received (OFC) and foregone (ACCs) reward signaling, ACCg emerged as an important nexus for the computation of shared experience and social reward. Individual and species-specific variations in social decision-making might result from the relative activation and influence of these areas.

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