2013年7月22日月曜日

Canceling actions involves a race between basal ganglia pathways

Robert Schmidt, Daniel K Leventhal, Nicolas Mallet, Fujun Chen & Joshua D Berke
Nature Neuroscience (2013) doi:10.1038/nn.3456
Received 22 March 2013 Accepted 31 May 2013 Published online 14 July 2013

実験課題:Goの合図の直後に「Stopの合図」が出る。
結果:視床下核(Subthalamic nucleus)神経細胞は常にStopの合図に反応する。一方、基底核回路の下流に位置する黒質網様部(substantia nigra pars reticulata)の神経細胞はStopが成功した時にのみ反応する。
結論:Race modelが示唆するように、視床下核から黒質網様部にかけて「行動の取り消し(stop)」に関与する神経回路が存在する。

Salient cues can prompt the rapid interruption of planned actions. It has been proposed that fast, reactive behavioral inhibition involves specific basal ganglia pathways, and we tested this by comparing activity in multiple rat basal ganglia structures during performance of a stop-signal task. Subthalamic nucleus (STN) neurons exhibited low-latency responses to 'Stop' cues, irrespective of whether actions were canceled or not. By contrast, neurons downstream in the substantia nigra pars reticulata (SNr) only responded to Stop cues in trials with successful cancellation. Recordings and simulations together indicate that this sensorimotor gating arises from the relative timing of two distinct inputs to neurons in the SNr dorsolateral 'core' subregion: cue-related excitation from STN and movement-related inhibition from striatum. Our results support race models of action cancellation, with stopping requiring Stop-cue information to be transmitted from STN to SNr before increased striatal input creates a point of no return.

0 件のコメント:

コメントを投稿