2013年10月24日木曜日

Extended practice of a motor skill is associated with reduced metabolic activity in M1.

Picard, N., Matsuzaka, Y., & Strick, P. L. (2013).
Nature neuroscience, 16(9), 1340–7.

運動(スキル)学習を行っても、一次運動野(M1)の神経活動(ニューロンの発火頻度)は変化しない。
しかし、それを支える代謝量は減少する。
つまり、スキル練習/学習によって、一次運動野の神経活動の効率が良くなる(少ない代謝で同じ活動を維持できるようになる)。

How does long-term training and the development of motor skills modify the activity of the primary motor cortex (M1)? To address this issue, we trained monkeys for ~1–6 years to perform visually guided and internally generated sequences of reaching movements. Then, we used [14C]2-deoxyglucose (2DG) uptake and single-neuron recording to measure metabolic and neuron activity in M1. After extended practice, we observed a profound reduction of metabolic activity in M1 for the performance of internally generated compared to visually guided tasks. In contrast, measures of neuron firing displayed little difference during the two tasks. These findings suggest that the development of skill through extended practice results in a reduction in the synaptic activity required to produce internally generated, but not visually guided, sequences of movements. Thus, practice leading to skilled performance results in more efficient generation of neuronal activity in M1.

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