2013年11月25日月曜日

What's better for me? Fundamental role for lateral habenula in promoting subjective decision biases

Colin M Stopper & Stan B Floresco
Nature Neuroscience (2013) doi:10.1038/nn.3587

Lateral habenula (LHb) の活動を抑制すると、「コスト(報酬の遅延や不確実性)と利益に基づく意思決定」ができなくなる。
一方、単なる報酬量の大小に基づく意思決定はできる。
→ LHbは「利益とコスト計算して選択肢の価値を評価する」ことに関わっている。

The lateral habenula (LHb) is believed to convey an aversive or 'anti-reward' signal, but its contribution to reward-related action selection is unknown. We found that LHb inactivation abolished choice biases, making rats indifferent when choosing between rewards associated with different subjective costs and magnitudes, but not larger or smaller rewards of equal cost. Thus, instead of serving as an aversion center, the evolutionarily conserved LHb acts as a preference center that is integral for expressing subjective decision biases.

0 件のコメント:

コメントを投稿