2013年12月26日木曜日

Causal Evidence of Performance Monitoring by Neurons in Posterior Cingulate Cortex during Learning

Sarah R. Heilbronner, Michael L. Platt
Neuron: Volume 80, Issue 6, 18 December 2013, Pages 1384–1391

サル電気生理+損傷研究。
後部帯状皮質の神経活動は実験課題の成績と逆相関することが知られている。
「成績が悪い→後部帯状皮質が活動」なのか?
「後部帯状皮質が活動→成績が悪い」なのか?
前者っぽい。
つまり、「後部帯状皮質は成績が悪いことを認知して、脳内のリソースを実験課題に集中させる」ことに関与している。

The posterior cingulate cortex (CGp) is a major hub of the default mode network (DMN), a set of cortical areas with high resting activity that declines during task performance. This relationship suggests that DMN activity contributes to mental processes that are antagonistic to performance. Alternatively, DMN may detect conditions under which performance is poor and marshal cognitive resources for improvement. To test this idea, we recorded activity of CGp neurons in monkeys performing a learning task while varying reward size and novelty. We found that CGp neurons responded to errors, and this activity was magnified by small reward and novel stimuli. Inactivating CGp with muscimol impaired new learning when rewards were small but had no effect when rewards were large; inactivation did not affect performance on well-learned associations. Thus, CGp, and by extension the DMN, may support learning, and possibly other cognitive processes, by monitoring performance and motivating exploration.

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