2015年3月18日水曜日

Dynamic routing of task-relevant signals for decision making in dorsolateral prefrontal cortex

Christopher H Donahue & Daeyeol Lee
Nature Neuroscience 18, 295–301 (2015)

前頭前野背外側部(dlPFC)は実験課題に関する様々な変数に反応することが知られているが、「本当に必要な変数」をどうやって識別しているのか?
→ dlPFCは実験課題遂行に必要な変数も必要でない変数もコードしているが、「必要な変数」だけが選択/意思決定と共に反応する。

Neurons in the dorsolateral prefrontal cortex (DLPFC) encode a diverse array of sensory and mnemonic signals, but little is known about how this information is dynamically routed during decision making. We analyzed the neuronal activity in the DLPFC of monkeys performing a probabilistic reversal task where information about the probability and magnitude of reward was provided by the target color and numerical cues, respectively. The location of the target of a given color was randomized across trials and therefore was not relevant for subsequent choices. DLPFC neurons encoded signals related to both task-relevant and irrelevant features, but only task-relevant mnemonic signals were encoded congruently with choice signals. Furthermore, only the task-relevant signals related to previous events were more robustly encoded following rewarded outcomes. Thus, multiple types of neural signals are flexibly routed in the DLPFC so as to favor actions that maximize reward.

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