2017年7月10日月曜日

Dissociation of Choice Formation and Choice-Correlated Activity in Macaque Visual Cortex

Robbe L.T. Goris, Corey M. Ziemba, Gabriel M. Stine, Eero P. Simoncelli and J. Anthony Movshon
Journal of Neuroscience 21 April 2017, 37 (20) 5195-5203;
DOI: https://doi.org/10.1523/JNEUROSCI.3331-16.2017

Responses of individual task-relevant sensory neurons can predict monkeys' trial-by-trial choices in perceptual decision-making tasks. Choice-correlated activity has been interpreted as evidence that the responses of these neurons are causally linked to perceptual judgments. To further test this hypothesis, we studied responses of orientation-selective neurons in V1 and V2 while two macaque monkeys performed a fine orientation discrimination task. Although both animals exhibited a high level of neuronal and behavioral sensitivity, only one exhibited choice-correlated activity. Surprisingly, this correlation was negative: when a neuron fired more vigorously, the animal was less likely to choose the orientation preferred by that neuron. Moreover, choice-correlated activity emerged late in the trial, earlier in V2 than in V1, and was correlated with anticipatory signals. Together, these results suggest that choice-correlated activity in task-relevant sensory neurons can reflect postdecision modulatory signals.

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